Jiyeon Son
Team Leader GC Biopharma Aseptic Fill-Finish & mRNA DS CDMO
Seminars
Wednesday 11th November 2026
Development of Lipid Nanoparticles for Precision mRNA Delivery: Advancing From Protein Replacement to In Vivo Genome Editing & CAR-T Cell Programming
5:00 pm
- Applying Structure-Activity Relationship (SAR) modeling and AI-guided molecular design to develop a proprietary lipid library with an optimized therapeutic index and enhanced clinical tolerability
- Identifying and selecting LNP formulations tailored for high-efficiency hepatic delivery, facilitating the technical transition from transient protein replacement to permanent genetic intervention with minimal off-target toxicity
- Developing LNP formulations specifically optimized to maximize T-cell delivery efficiency, enabling precise in vivo CAR-T cell programming through systemic mRNA delivery
