Seigo Kimura
Assistant Professor Nagoya University
Seminars
Wednesday 11th November 2026
A Branched Ionizable Lipid Nanoparticle Platform for Versatile In Vivo Delivery of Nucleic Acids: Validation From mRNA to Capped Circular RNA
5:00 pm
- Developing a branched ionizable lipid nanoparticle (FL0445-LNP) that enables potent delivery of both linear mRNA and Cap-cirRNA
- Exploring how FL0445‑LNP exhibits an improved safety profile with reduced immunogenicity compared with clinical benchmark LNPs
- Sharing how Cap‑cirRNA delivered via FL0445‑LNP achieves superior glycemic control over linear mRNA in obese mice
