Development of Lipid Nanoparticles for Precision mRNA Delivery: Advancing From Protein Replacement to In Vivo Genome Editing & CAR-T Cell Programming

• Applying Structure-Activity Relationship (SAR) modeling and AI-guided molecular design to develop a proprietary lipid library with an optimized therapeutic index and enhanced clinical tolerability
• Identifying and selecting LNP formulations tailored for high-efficiency hepatic delivery, facilitating the technical transition from transient protein replacement to permanent genetic intervention with minimal off-target toxicity
• Developing LNP formulations specifically optimized to maximize T-cell delivery efficiency, enabling precise in vivo CAR-T cell programming through systemic mRNA delivery

Speakers:

Jiyeon Son

Team Leader

GC Biopharma Aseptic Fill-Finish & mRNA DS CDMO